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11.10. Type 1 diabetes in diverse ancestries and the use of genetic risk scores

MJ Redondo , CR Gignoux , D Dabelea , WA Hagopian , S Onengut-Gumuscu , RA Oram , SS Rich

Brief summary: This review article discusses the influence of genetics on type 1 diabetes (T1D), particularly with regard to differences across diverse genetic ancestries, and the development of validated genetic risk scores (GRS) for use various populations. These may contribute to disease prevention and treatment.The autoimmune destruction of pancreatic beta cells is triggered by the interaction of genetic predisposition and environmental factors. T1D ...

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ey0017.10-4 | (1) | ESPEYB17

10.4. Association of gluten intake during the first 5 years of life with incidence of celiac disease autoimmunity and celiac disease among children at increased risk

CA Aronsson , H-S Lee , EM Hardaf Segerstad , U Uusitalo , J Yang , S Koletzko , E Liu , K Kurppa , PJ Bingley , J Toppari , AG Ziegler , J-X She , WA Hagopian , M Rewers , B Akolkar , JP Krischer , SM Virtanen , JM Norris , D Agardh , for the TEDDY Study Group

To read the full abstract: JAMA. 2019;322(6):514523. doi: 10.1001/jama.2019.10329Some children have a high genetic risk to develop type 1 diabetes (T1DM) and/or celiac disease. However, environmental factors may modify such risks. One arm of the TEDDY study assessed the influence of high gluten intakes on the development of celiac disease in genetically high risk children.<p clas...

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ESPE Yearbook of Paediatric Endocrinology

11.10. Type 1 diabetes in diverse ancestries and the use of genetic risk scores

10.4. Association of gluten intake during the first 5 years of life with incidence of celiac disease autoimmunity and celiac disease among children at increased risk

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